Psalm 22:16
"For dogs have compassed me: the assembly of the wicked have inclosed me: they pierced my hands and my feet."

Messianic Biblical position as written by Shalach Ministries:

Psalm 22:16.  Nowhere in the entirety of this Psalm does it state that King David was not prophesying about the Messiah.  Why should this Psalm not be Christological?  We need to focus on the entirety of the Psalm in determining its Christological value rather than just one word "pierced".  Although, the Hebrew definition of the word "pierced" means "lion", this has little translation effect on the Scriptural meanings themselves.  

If we translate this Psalm with the Hebrew word "pierced" as defined above then it would read "they were like a lion at my hands and my feet."  As we all know Lions tear at the flesh of their prey [victim] just as the spikes driven through Jesus' hands and feet tore at His flesh when He was crucified.  There are no less than five Messianic passages prophesied in this Psalm:

blue bullet   Psalm 22:1  "My God, my God, why hast thou forsaken me? why art thou so far from helping me, and from the words of my roaring?" Matthew 27:46  "And about the ninth hour Jesus cried with a loud voice, saying, Eli, Eli, lama sabachthani? that is to say, My God, my God, why hast thou forsaken me?"

blue bullet   Psalm 22:8  "He trusted on the LORD that he would deliver him: let him deliver him, seeing he delighted in him." Matthew 27:43  "He trusted in God; let him deliver him now, if he will have him: for he said, I am the Son of God." 

blue bullet   Psalm 22:16  "For dogs have compassed me: the assembly of the wicked  have inclosed me: they pierced my hands and my feet." St. John 19:  "And again another scripture saith, They shall look on him whom they pierced" (Zechariah 12:10).   

blue bullet   Psalm 22:18  "They part my garments among them, and cast lots upon my vesture." Matthew 27:35  "And they crucified him, and parted his garments, casting lots: that it might be fulfilled which was spoken by the prophet, They parted my garments among them, and upon my vesture did they cast lots."   

blue bullet   Psalm 22:22   "I will declare thy name unto my brethren: in the midst of the congregation will I praise thee."  Hebrews 2:12  "Saying, I will declare thy name unto my brethren, in the midst of the church will I sing praise unto thee."   

If we use the translation from the Tanakh Bible written by the Jewish Publication Society (JPS), it reads: "For dogs have encompassed me; a company of evil-doers have inclosed me; like a lion, they are at my hands and my feet."

In summary, in conjunction with other Scriptural evidence it is far more likely to support Psalm 22 as Messianic than to merely say it has no Christological substance at all.