The Messiah would suffer great sorrow and grief.
OT Prophecy NT Fulfillment
Isaiah 53:3c
"He is despised and rejected of men; a man of sorrows, and acquainted with grief: and we hid as it were our faces from him; he was despised, and we esteemed him not."
Luke 19:41–42
[41] And when he was come near, he beheld the city, and wept over it.
[42] Saying, If thou hadst known, even thou, at least in this thy day, the things which belong unto thy peace! but now they are hid from thine eyes.

Matthew 26:37–38
[37] And he took with him Peter and the two sons of Zebedee, and began to be sorrowful and very heavy.
[38] Then saith he unto them, My soul is exceeding sorrowful, even unto death: tarry ye here, and watch with me.

Matthew 27:46
"And about the ninth hour Jesus cried with a loud voice, saying, Eli, Eli, lama sabachthani? that is to say, My God, my God, why hast thou forsaken me?"
Tanakh – Neviim – Isaiah 53:3c
"He was despised, and forsaken of men, a man of pains, and acquainted with disease, and as one from whom men hide their face: he was despised, and we esteemed him not."
Hebrew OT – Isaiah 53:3c
[53:3] נִבְזֶה וַחֲדַל אִישִׁים
אִישׁ מַכְאֹבוֹת וִידוּעַ חֹלִי
וּכְמַסְתֵּר פָּנִים מִמֶּנּוּ
נִבְזֶה וְלֹא חֲשַׁבְנֻהוּ